Formulasi dan Uji Aktivitas Antibakteri Gel Minyak Atsiri Rimpang Lengkuas Merah (Alpinia purpurata K. Schum) terhadap Propionibacterium acnes
DOI:
https://doi.org/10.55123/insologi.v4i1.4844Keywords:
Alpinia Purpurata K. Schum, Acne, Propionibacterium Acnes, Essential Oil Gel, AntibacterialAbstract
Acne is a common dermatological condition caused by the bacterial infection of Propionibacterium acnes, leading to skin inflammation. Red galangal (Alpinia purpurata K. Schum) is known to exhibit antibacterial activity due to its essential oil content, flavonoids, and alkaloids. This study aims to formulate and evaluate the antibacterial activity of a gel preparation based on red galangal rhizome essential oil against Propionibacterium acnes. The research follows a laboratory experimental design, including the extraction of red galangal rhizome essential oil via maceration, formulation of the gel, and evaluation of its physical properties, such as pH, homogeneity, spreadability, and antibacterial activity using the disc diffusion method. The results demonstrated that the gel formulation met the required physicochemical standards, with a pH ranging from 6.4 to 6.8, good homogeneity, and an optimal spreadability of 5–7 cm. The antibacterial test revealed a significant inhibitory effect against Propionibacterium acnes, with an inhibition zone of up to 11.24 mm at a 15% concentration. These findings suggest that red galangal rhizome essential oil possesses strong antibacterial potential, making it a promising candidate for natural topical acne treatment. In conclusion, the red galangal essential oil gel exhibits favorable antibacterial activity against Propionibacterium acnes and has potential as an alternative acne treatment. Further studies are necessary to enhance the stability and efficacy of the formulation for optimal clinical applications.
Downloads
References
Dalimunthe, Aminah, Poppy Anjelisa Zaitun Hasibuan, Jansen Silalahi, Siti Fatimah Sinaga, and Denny Satria. 2018. ‘Antioxidant Activity of Alkaloid Compounds from Litsea Cubeba Lour’. Oriental Journal of Chemistry 34(2):1149.
Dissanayake, Kankanam Gamage Chithramala, WALC Waliwita, and Ruwan Priyantha Liyanage. 2020. ‘A Review on Medicinal Uses of Zingiber Officinale (Ginger)’. International Journal of Health Sciences and Research 10(6):142–48.
Fitri, Raissa, Hariyadi Dharmawan Syahputra, Nasri Nasri, Vera Estefania Kaban, and Zulmai Rani. 2022. ‘FORMULATION OF A BIOCELLULOSE MASK CONTAINING THE ESSENCE OF ALOE VERA (L.) BURM. F COMBINATION WITH VITAMIN E AS ANTI-AGING.’ ScienceRise: Pharmaceutical Science 40(6).
Harahap, Nina Irmayanti, Zola Efa Harnis, and Sri Rezeky. 2022. ‘Anti-Bacterial Activity Testing Of Batak (Allium Chinense G. Don.) Leaf Ethanol Extract Against The Bacteria Propionibacterium Acnes, Staphylococcus Aureus, Escherichia Coli And Salmonella Thyph’. Journal of Midwifery and Nursing 4(3):69–73.
Hikmah, Febrial, and Hasanah Nur. 2023. ‘Uji Hambat Aktivitas Bakteri Propionibacterium Acnes Terhadap Ekstrak Etanol Rimpang Lengkuas Merah (Alpinia Purpurata (K.) Schum)’. Jurnal Medika Udayana 12(1):74–84.
Kaban, Vera Estefania. 2021. ‘Uji Formula Krim Ekstrak VCO Kunyit Dari Rimpang Kunyit (Curcuma Domestica Val.) Terhadap Penghambatan Perkembangan Sel Melanoma’. PhD Thesis, Universitas Sumatera Utara.
Kaban, Vera Estefania, Jessi Octavia Aritonang, Yulia Citra Hasibuan, and Dian Ika Perbina Meliala. 2020. ‘Efektivitas Penyembuhan Luka Sayat Menggunakan Salep Ekstrak Etanol Daun Senggani (Melastoma Malabathricum L.) Pada Kelinci’. Jurnal Penelitian Farmasi & Herbal 2(2):8–14.
Kaban, Vera Estefania, Junius Gian Ginting, Nasri Nasri, Hasel Untung Bersinar Sagala, and Serly Annisa Br Tarigan. 2024. ‘Uji Efektivitas Gel Ekstrak Daun Jarak Pagar (Jatropha Curcas L.) Sebagai Penyembuhan Luka Sayat’. INSOLOGI: Jurnal Sains Dan Teknologi 3(4):432–41.
Kaban, Vera Estefania, Nasri Nasri, Kasta Gurning, Hariyadi Dharmawan Syahputra, and Zulmai Rani. 2022. ‘Formulasi Sediaan Lip Cream Ekstrak Daun Miana (Coleus Scuatellariodes [L] Benth.) Sebagai Pewarna Alami’. INSOLOGI: Jurnal Sains Dan Teknologi 1(4):393–400.
Kaban, Vera Estefania, Nasri Nasri, Zulmai Rani, Nurul Suci, Elva Swandi Karo Sekali, and Hasel Untung Bersinar Sagala. 2024. ‘The Effect of Turmeric Parent Extract Gel (Curcuma Longa Linn) on Incision Wound Healing in Male White Rats (Rattus Norvegicus)’. Journal of Pharmaceutical and Sciences 616–27.
Kaban, Vera Estefania, Nasri Nasri, Hariyadi Dharmawan Syahputra, Raissa Fitri, Zulmai Rani, and Muhammad Fauzan Lubis. 2022. ‘Formulasi Sediaan Gel Dari Ekstrak Metanol Biji Alpukat (Persea Americana Mill.) Sebagai Penyembuh Luka Sayat Pada Tikus Jantan (Rattus Norvegicus)’. Herbal Medicine Journal 5(2):48–54.
Kaban, Vera Estefania, Nasri Nasri, Hariyadi Dharmawan Syahputra, Muhammad Fauzan Lubis, and Denny Satria. 2023. ‘Uji Aktivitas Antibakteri Ekstrak Daun Karenda (Carissa Carandas Linn.) Terhadap Bakteri Propionibacterium Acne Dan Staphylococcus Epidermidis’. Journal of Pharmaceutical and Health Research 4(1):91–96.
Kaban, Vera Estefania, Nur Ain Thomas, and Inayatush Sholihah. n.d. ‘PENGANTAR ILMU FARMASI’.
Kaban, Vera Estefania, and Siti Yusmarlisa. 2018. ‘Uji Aktivitas Kandungan Antioksidan Pada Daun Bangun-Bangun (Plectranthus Amboinicus) Secara Spektrofotometri Ultraviolet-Visible’. Jurnal Farmasimed (JFM) 1(1):16–20.
Lakshmi, SVVNSM, Suryam Gugulothu, Chandan Mohanty, T. Venkatachalam, and Chandan Nayak. 2022. ‘DEVELOPMENT AND EVALUATION OF ANTI-INFLAMMATORY GEL CONTAINING ZINGER OFFICINALE.’ NeuroQuantology 20(12):1030.
Lubis, M. F., V. E. Kaban, J. O. Aritonang, D. Satria, A. A. Mulina, and H. Febriani. 2022. ‘Acute Toxicity and Antifungal Activity of the Ointment Murraya Koenigii Ethanol Extract’. Rasayan J. Chem 15(1):256–61.
Lubis, Muhammad Fauzan, Poppy Anjelisa Zaitun Hasibuan, Hafid Syahputra, Jane Melita Keliat, Vera Estefania Kaban, and Ririn Astyka. 2023. ‘Duku (Lansium Domesticum) Leaves Extract Induces Cell Cycle Arrest and Apoptosis of HepG2 Cells via PI3K/Akt Pathways’. Trends in Sciences 20(2):6437–6437.
Mahfud, Mahfud, M. Dwiki Darmawan, Derrick Hertha Diamanta, and Heri Septya Kusuma. 2017. ‘Extraction of Essential Oil from Bangle (Zingiber Purpureum Roxb.) by Hydrodistillation and Steam Distillation Methods’. Journal of Chemical Technology and Metallurgy 52(5):791–96.
Mas’uliyah, Nur Ummu. 2023. ‘Perbandingan Ekstrak Kasar Dengan Fraksi Ekstrak Metanol Rimpang Lengkuas Merah (Alpinia Purpurata K. Schum) Terhadap Daya Hambat Staphylococcus Aureus Dan Escherichia Coli’.
Mohsin, Noreen, Loren E. Hernandez, Mackenzie R. Martin, Ashley Vander Does, and Keyvan Nouri. 2022. ‘Acne Treatment Review and Future Perspectives’. Dermatologic Therapy 35(9). doi: 10.1111/dth.15719.
Nasri, Nasri, Vera Estefania Kaban, Denny Satria, Hariyadi Dharmawan Syahputra, and Zulmai Rani. 2023. ‘Mekanisme Antibakteri Ekstrak Etanol Daun Kemangi (Ocimum Basilicum L.) Terhadap Salmonella Typhi’. Journal of Pharmaceutical and Health Research 4(1):79–84.
Nasri, Nasri, Denny Satria, Vera Estefania Kaban, Chyntia Glori Tania, Hariyadi Dharmawan Syahputra, and Zulmai Rani. 2024. ‘Antibacterial Potential of Ethanolic Extract of Avocado Leaves (Persea Americana Mill.) against Clinical Isolate of Klebsiella Pneumoniae and Proteus Mirabilis’. Trends in Sciences 21(7):7821–7821.
Nasri, Nasri, Jansen Silalahi, Vera Estefania Kaban, and Denny Satria. 2023. ‘A Review on The Benefits of Probiotics as Fermented Food against Several Diseases’. Journal of Functional Food and Nutraceutical 41–52.
Nurlaila, Sucia Rahmadani, Ayu Desi Rachmadani, and Kun Harismah. 2022. ‘Formulation and Evaluation of Physical Stability Natural Acne Gel Based on Aloevera Gel with Essential Oil Blend’. Urecol Journal. Part D: Applied Sciences 2(1):34–42.
Rumaseuw, Ellen Stephanie, Vera Estefania Kaban, Agung Wibawa Mahatva Yodha, Yulianita Pratiwi Indah Lestari, Asti Vebriyanti Asjur, Muh Taufiqurrahman, Hamsidar Hasan, and Teguh Adiyas Putra. 2023. Farmakognosi. Global Eksekutif Teknologi.
Satria, Denny, Aminah Dalimunthe, Dewi Pertiwi, Mahatir Muhammad, Vera Estefania Kaban, Nasri Nasri, and Syukur Berkat Waruwu. 2023. ‘Phytochemicals, Proximate Composition, Minerals and Volatile Oil Analysis of Zanthoxylum Acanthopodium DC. Fruits’. F1000Research 12:227.
Syahputra, Hariyadi Dharmawan, Nasri Nasri, and Vera Estefania Kaban. 2022. ‘Pengujian Potensi Aktivitas Antibakteri Dari Daun Cep-Cepan (Saurauia Cauliflora DC.) Dalam Formulasi Sediaan Gel Terhadap Propionibacterium Acnes’. Herbal Medicine Journal 5(1):28–32.
Vera, Vera Estefania Kaban, and Jansen Silalahi. 2022. ‘Testing Of The Cream Formula Turmina Right Extract Against The Inhibition Of The Development Of Melanoma Cells’. International Journal of Science, Technology & Management 3(2):525–29.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Astriani Natalia Br Ginting, Vera Estefania Kaban, Roy Indrianto Bangar, Daimah W. S. Harahap
This work is licensed under a Creative Commons Attribution 4.0 International License.
Hak cipta pada setiap artikel adalah milik penulis.
Penulis mengakui bahwa INSOLOGI (Jurnal Sains dan Teknologi) sebagai publisher yang mempublikasikan pertama kali dengan lisensi Creative Commons Attribution 4.0 International License.
Penulis dapat memasukan tulisan secara terpisah, mengatur distribusi non-ekskulif dari naskah yang telah terbit di jurnal ini kedalam versi yang lain, seperti: dikirim ke respository institusi penulis, publikasi kedalam buku, dan lain-lain. Dengan mengakui bahwa naskah telah terbit pertama kali pada INSOLOGI (Jurnal Sains dan Teknologi).
