Aktivitas Gel Ekstrak Daun Kepel terhadap Staphylococcus epidermidis FNCC 0048 dan Escherichia coli FNCC 0091
DOI:
https://doi.org/10.55123/insologi.v5i3.8095Keywords:
Antibacterial, Kepel, Staphylococcus epidermidis FNCC 0048, Escherichia coli FNCC0091, GelAbstract
Infection is one of the health problems that many people experience, skin infections caused by Staphylococcus epidermidis FNCC 0048 bacteria and diarrheal diseases caused by Escherichia coli FNCC0091 bacteria. This aims of this study to determine gel concentration of antibacterial activity from ethanol extract of Kepel leaves (Stelechocarpus burahol) which shows antibacterial activity against Staphylococcus epidermidis FNCC 0048 and Escherichia coli FNCC0091. This study is an experimental study, using the well-diffusion method and the diameter of the inhibition zone. The concentrations of the Kepel leaf ethanol extract used in this study were 6%, 9%, and 12%. The analysis used is descriptive analysis. The results of the physical property tests showed that the emulgel of kepel extract had good organoleptic properties, adhesiveness, and pH. However, its spreadability did not meet the standard criteria. The results showed that the gel extract of Kepel leaves (Stelechocarpus burahol) with a concentration of 6%, 9%, and 12% was able to inhibit the growth of Staphylococcus epidermidis FNCC 0048 bacteria with an average of 2.13mm, 4.15mm, and 5.47mm respectively, while for bacteria Escherichia coli FNCC0091 with an average of 2.44mm, 3.55mm and 4.14mm respectively.The minimum concentration of ethanol extract of Kepel leaves which shows antibacterial activity against test bacteria is 3%.
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Cushnie TPT, Cushnie B, Lamb AJ. (2016). Alkaloids: An overview of their antibacterial properties. Int J Antimicrob Agents. 2016;44(5):377–386. doi:10.1016/j.ijantimicag.2016.06.001
Borges A, Abreu AC, Ferreira C, Saavedra MJ, Simões LC, Simões M. (2016). Antibacterial activity and mode of action of plant extracts. Microb Drug Resist. 2016;22(7):588–595. doi:10.1089/mdr.2015.0104
Nazzaro F, Fratianni F, Coppola R, De Feo V.(2017). Essential oils and antimicrobial activity. Pharmaceuticals. 2017;10(4):86. doi:10.3390/ph10040086
Gupta PD, Birdi TJ.(2017). Development of botanicals to combat antibiotic resistance. Indian J Med Res. 2017;146(4):455–465. doi:10.4103/ijmr.IJMR_149_17
Daglia M.(2018). Polyphenols as antimicrobial agents. Curr Opin Biotechnol. 2018;56:123–129. doi:10.1016/j.copbio.2018.11.001
Othman L, Sleiman A, Abdel-Massih RM. (2019). Antimicrobial activity of plant extracts. Evid Based Complement Alternat Med. 2019;2019:1–14. doi:10.1155/2019/8154570
Silva NCC, Fernandes Júnior A. (2019). Biological properties of medicinal plants. J Venom Anim Toxins Incl Trop Dis. 2019;25:e20190001. doi:10.1590/1678-9199-JVATITD-2019-0001
Breijyeh Z, Jubeh B, Karaman R. (2020). Resistance of Gram-negative bacteria to antibiotics. Molecules. 2020;25(6):1340. doi:10.3390/molecules25061340
Cheesman MJ, Ilanko A, Blonk B, Cock IE.(2017). Developing new antimicrobial therapies. Pharmacogn Rev. 2017;11(22):119–126. doi:10.4103/phrev.phrev_51_16
Cowan MM. (2016). Plant products as antimicrobial agents revisited. Clin Microbiol Rev. 2016;29(3):629–643. doi:10.1128/CMR.00002-16
Savoia D. (2018). Plant-derived antimicrobial compounds. Future Microbiol. 2018;13(2):215–234. doi:10.2217/fmb-2017-0190
Barbieri R, Coppo E, Marchese A, Daglia M, Sobarzo-Sánchez E, Nabavi SF, et al. (2017). Phytochemicals for human disease. Biomed Pharmacother. 2017;96:110–124. doi:10.1016/j.biopha.2017.09.076
Chouhan S, Sharma K, Guleria S. (2017). Antimicrobial activity of essential oils. Medicines. 2017;4(3):58. doi:10.3390/medicines4030058
Tacconelli E, Carrara E, Savoldi A, et al. (2018). Global antimicrobial resistance report. Lancet Infect Dis. 2018;18(3):318–327. doi:10.1016/S1473-3099(17)30753-3
Ventola CL.(2015). Antibiotic resistance crisis. Pharm Ther. 2015;40(4):277–283. doi:10.1007/s40265-015-0408-9
Karaman I, Şahin F, Güllüce M, Öğütçü H, Şengül M, Adıgüzel A.(2016). Antimicrobial activity of plant extracts. J Ethnopharmacol. 2016;85(2–3):231–236. doi:10.1016/S0378-8741(03)00085-5
Hemeg HA. (2017). Nanoparticles and plant extracts antibacterial activity. Saudi J Biol Sci. 2017;24(6):1289–1296. doi:10.1016/j.sjbs.2016.01.019
Altemimi A, Lakhssassi N, Baharlouei A, Watson DG, Lightfoot DA. (2017). Phytochemicals and their role. Plants. 2017;6(4):42. doi:10.3390/plants6040042
Miklasińska-Majdanik M, et al. (2018). Mechanisms of biofilm resistance. Int J Mol Sci. 2018;19(1):152. doi:10.3390/ijms19010152
Yap PSX, Yiap BC, Ping HC, Lim SHE. (2017). Essential oils antibacterial activity. Front Microbiol. 2017;5:1–12. doi:10.3389/fmicb.2017.00258
Nostro A, Papalia T. (2016). Antimicrobial activity of plant extracts. Microbiol Res. 2016;181:30–36. doi:10.1016/j.micres.2015.09.003
Silva LN, Zimmer KR, Macedo AJ, Trentin DS. (2016). Plant extracts antimicrobial activity. J Appl Microbiol. 2016;121(5):1219–1230. doi:10.1111/jam.13275
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